A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

Loss of the CDK inhibitor p27(KIP1) is widely linked with poor prognosis in human cancer. In Wnt10b-expressing mammary tumors, levels of p27(KIP1) were extremely low; conversely, Wnt10b-null mammary cells expressed high levels of this protein, suggesting Wnt-dependent regulation of p27(KIP1). Intere...

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Autors principals: Miranda-Carboni, Gustavo A., Krum, Susan A., Yee, Kathleen, Nava, Miguel, Deng, Qiming E., Pervin, Shehla, Collado-Hidalgo, Alicia, Galić, Zoran, Zack, Jerome A., Nakayama, Keiko, Nakayama, Keiichi I., Lane, Timothy F.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593606/
https://ncbi.nlm.nih.gov/pubmed/19056892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1692808
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