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Residues in the 11 Å Channel of Histone Deacetylase 1 Promote Catalytic Activity: Implications for Designing Isoform-Selective Histone Deacetylase Inhibitors

Histone deacetylase 1 (HDAC1) has been linked to cell growth and cell cycle regulation, which makes it a widely recognized target for anticancer drugs. Whereas variations of the metal-binding and capping groups of HDAC inhibitors have been studied extensively, the role of the linker region is less w...

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Bibliografische gegevens
Hoofdauteurs: Weerasinghe, Sujith V. W., Estiu, Guillermina, Wiest, Olaf, Pflum, Mary Kay H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593471/
https://ncbi.nlm.nih.gov/pubmed/18729444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800081j
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