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Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination

Interferon regulatory factor 5 (IRF-5) plays an important role in the innate antiviral and inflammatory response. Specific IRF-5 haplotypes are associated with dysregulated expression of type I interferons and predisposition to autoimmune disorders. IRF-5 is activated by Toll-like receptor 7 (TLR7)...

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Bibliografiske detaljer
Main Authors: Balkhi, Mumtaz Yaseen, Fitzgerald, Katherine A., Pitha, Paula M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593423/
https://ncbi.nlm.nih.gov/pubmed/18824541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00662-08
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