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Dissection of the Molecular Defects Caused by Pathogenic Mutations in the DNA Repair Factor XPC
XPC is responsible for DNA damage sensing in nucleotide excision repair (NER). Mutations in XPC lead to a defect in NER and to xeroderma pigmentosum (XP-C). Here, we analyzed the biochemical properties behind mutations found within three patients: one amino acid substitution (P334H, XP1MI, and GM020...
Gorde:
| Egile Nagusiak: | , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Microbiology (ASM)
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593387/ https://ncbi.nlm.nih.gov/pubmed/18809580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00781-08 |
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