Regulatory Role of Human AP-Endonuclease (APE1/Ref-1) in YB-1-Mediated Activation of the Multidrug Resistance Gene MDR1

Human AP-endonuclease (APE1/Ref-1), a central enzyme involved in the repair of oxidative base damage and DNA strand breaks, has a second activity as a transcriptional regulator that binds to several trans-acting factors. APE1 overexpression is often observed in tumor cells and confers resistance to...

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Auteurs principaux: Chattopadhyay, Ranajoy, Das, Soumita, Maiti, Amit K., Boldogh, Istvan, Xie, Jingwu, Hazra, Tapas K., Kohno, Kimitoshi, Mitra, Sankar, Bhakat, Kishor K.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593380/
https://ncbi.nlm.nih.gov/pubmed/18809583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00244-08
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