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Control of Cellular GADD34 Levels by the 26S Proteasome

GADD34, the product of a growth arrest and DNA damage-inducible gene, is expressed at low levels in unstressed cells. In response to stress, the cellular content of GADD34 protein increases and, on termination of stress, rapidly declines. We investigated the mechanisms that control GADD34 levels in...

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Библиографические подробности
Главные авторы: Brush, Matthew H., Shenolikar, Shirish
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593369/
https://ncbi.nlm.nih.gov/pubmed/18794359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00724-08
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