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A maternal-zygotic effect gene Zfp57 maintains both maternal and paternal imprints
The mechanisms responsible for maintaining genomic methylation imprints in mouse embryos are not understood. We generated a knockout mouse in the Zfp57 locus encoding a KRAB zinc finger protein. Loss of just the zygotic function of Zfp57 causes partial neonatal lethality, while eliminating both mate...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593089/ https://ncbi.nlm.nih.gov/pubmed/18854139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.08.014 |
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