Zinc Finger Protein ZFP57 Requires Its Co-factor to Recruit DNA Methyltransferases and Maintains DNA Methylation Imprint in Embryonic Stem Cells via Its Transcriptional Repression Domain

Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation genomic imprint at multiple imprinted regions in mouse embryos. Despite these findings, it remains elusive how DNA methyltransferases are targeted to the imprinting control regions to initiate an...

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Detalhes bibliográficos
Main Authors: Zuo, Xiaopan, Sheng, Jipo, Lau, Ho-Tak, McDonald, Carol M., Andrade, Monica, Cullen, Dana E., Bell, Fong T., Iacovino, Michelina, Kyba, Michael, Xu, Guoliang, Li, Xiajun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265890/
https://ncbi.nlm.nih.gov/pubmed/22144682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322644
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