Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

PSI-6130 (β-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine) is a selective inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase. R7128, the prodrug of PSI-6130, has shown antiviral efficacy in patients chronically infected with HCV genotype 1a (GT-1a) and GT-1b. We observed th...

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Hlavní autoři: Ali, Samir, Leveque, Vincent, Le Pogam, Sophie, Ma, Han, Philipp, Friederike, Inocencio, Nicole, Smith, Mark, Alker, Andre, Kang, Hyunsoon, Najera, Isabel, Klumpp, Klaus, Symons, Julian, Cammack, Nick, Jiang, Wen-Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592884/
https://ncbi.nlm.nih.gov/pubmed/18838588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00444-08
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