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Gain-of-Function Mutations in the Transcription Factor MRR1 Are Responsible for Overexpression of the MDR1 Efflux Pump in Fluconazole-Resistant Candida dubliniensis Strains

Candida dubliniensis, a yeast that is closely related to Candida albicans, can rapidly develop resistance to the commonly used antifungal agent fluconazole in vitro and in vivo during antimycotic therapy. Fluconazole resistance in C. dubliniensis is usually caused by constitutive overexpression of t...

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書誌詳細
主要な著者: Schubert, Sabrina, Rogers, P. David, Morschhäuser, Joachim
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592883/
https://ncbi.nlm.nih.gov/pubmed/18809934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00740-08
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