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Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin

Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of unknown protein(s) by the proteasome, formation of the Nalp1b (NLRP1b) inflammasome, and subsequent activation of caspase-1. We report that heat shocking LT-sensitive macrophag...

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Detalhes bibliográficos
Main Authors: Levin, Tera C., Wickliffe, Katherine E., Leppla, Stephen H., Moayeri, Mahtab
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592509/
https://ncbi.nlm.nih.gov/pubmed/18671821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2008.01220.x
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