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Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin
Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of unknown protein(s) by the proteasome, formation of the Nalp1b (NLRP1b) inflammasome, and subsequent activation of caspase-1. We report that heat shocking LT-sensitive macrophag...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2592509/ https://ncbi.nlm.nih.gov/pubmed/18671821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2008.01220.x |
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