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Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
SUMMARY: Anthrax lethal toxin (LT) is cytotoxic to macrophages from certain inbred mouse strains. The gene controlling macrophage susceptibility to LT is Nalp1b. Nalp1b forms part of the inflammasome, a multi-protein complex involved in caspase-1 activation and release of interleukin (IL)-1β and IL-...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515708/ https://ncbi.nlm.nih.gov/pubmed/17850338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2007.01044.x |
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