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Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome

SUMMARY: Anthrax lethal toxin (LT) is cytotoxic to macrophages from certain inbred mouse strains. The gene controlling macrophage susceptibility to LT is Nalp1b. Nalp1b forms part of the inflammasome, a multi-protein complex involved in caspase-1 activation and release of interleukin (IL)-1β and IL-...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Wickliffe, Katherine E., Leppla, Stephen H., Moayeri, Mahtab
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515708/
https://ncbi.nlm.nih.gov/pubmed/17850338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2007.01044.x
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