Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to provide a quantitative assessment of factors secreted by senescent cells. We show that human cells i...

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Bibliographische Detailangaben
Hauptverfasser: Coppé, Jean-Philippe, Patil, Christopher K, Rodier, Francis, Sun, Yu, Muñoz, Denise P, Goldstein, Joshua, Nelson, Peter S, Desprez, Pierre-Yves, Campisi, Judith
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592359/
https://ncbi.nlm.nih.gov/pubmed/19053174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060301
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