Phase I Clinical Evaluation of rDEN4Δ30-200,201: A Live Attenuated Dengue 4 Vaccine Candidate Designed for Decreased Hepatotoxicity

The rDEN4Δ30-200,201 is a live attenuated DENV-4 vaccine candidate specifically designed to further attenuate the rDEN4Δ30 parent virus. In the present study, 28 healthy adult volunteers were randomized to receive either 10(5) plaque-forming unit (PFU) of vaccine (20) or placebo (8) as a single subc...

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Main Authors: McArthur, Julie H., Durbin, Anna P., Marron, Jennifer A., Wanionek, Kimberli A., Thumar, Bhavin, Pierro, Dennis J., Schmidt, Alexander C., Blaney, Joseph E., Murphy, Brian R., Whitehead, Stephen S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590927/
https://ncbi.nlm.nih.gov/pubmed/18981503
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