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Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors

S-adenosylhomocysteine hydrolase (SAHH) is a ubiquitous enzyme that plays a central role in methylation-based processes by maintaining the intracellular balance between S-adenosylhomocysteine (SAH) and S-adenosylmethionine. We report the first prokaryotic crystal structure of SAHH, from Mycobacteriu...

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Autors principals: Reddy, Manchi C.M., Kuppan, Gokulan, Shetty, Nishant D., Owen, Joshua L., Ioerger, Thomas R., Sacchettini, James C.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590921/
https://ncbi.nlm.nih.gov/pubmed/18815415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.038125.108
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