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Recombinant Collagen Studies Link the Severe Conformational Changes Induced by Osteogenesis Imperfecta Mutations to the Disruption of a Set of Interchain Salt Bridges

The clinical severity of Osteogenesis Imperfecta (OI), also known as the brittle bone disease, relates to the extent of conformational changes in the collagen triple helix induced by Gly substitution mutations. The lingering question is why Gly substitutions at different locations of collagen cause...

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Bibliografiske detaljer
Main Authors: Xu, Ke, Nowak, Iwona, Kirchner, Michele, Xu, Yujia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590706/
https://ncbi.nlm.nih.gov/pubmed/18845533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805485200
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