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Perinatal Loss of Nkx2-5 Results in Rapid Conduction and Contraction Defects

Homeobox transcription factor Nkx2-5, highly expressed in heart, is a critical factor during early embryonic cardiac development. In this study, using tamoxifen-inducible Nkx2-5 knockout mice, we demonstrate the role of Nkx2-5 in conduction and contraction in neonates within 4 days after perinatal t...

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Detalhes bibliográficos
Main Authors: Briggs, Laura E., Takeda, Morihiko, Cuadra, Adolfo E., Wakimoto, Hiroko, Marks, Melissa H., Walker, Alexandra J., Seki, Tsugio, Oh, Suk P., Lu, Jonathan T., Sumners, Colin, Raizada, Mohan K., Horikoshi, Nobuo, Weinberg, Ellen O., Yasui, Kenji, Ikeda, Yasuhiro, Chien, Kenneth R., Kasahara, Hideko
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590500/
https://ncbi.nlm.nih.gov/pubmed/18689573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.171835
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