Contribution of the B oligomer to the protective activity of genetically attenuated pertussis toxin.

An enzymatically deficient recombinant S1 subunit, in which Arg-9 was replaced by Lys, was combined with native B oligomer to form a mutant holotoxin molecule. This molecule exhibited decreased leukocytosis-promoting and histamine-sensitizing activities compared with those of the native toxin, suppo...

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Bibliographic Details

Published in:	Infect Immun
Main Authors:	Arciniega, J L, Shahin, R D, Burnette, W N, Bartley, T D, Whiteley, D W, Mar, V L, Burns, D L
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1991
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258899/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1894354/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.59.10.3407-3410.1991
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