Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

BACKGROUND: Huntington's disease is a progressive autosomal dominant neurodegenerative disorder that is caused by a CAG repeat expansion in the HD or Huntington's disease gene. Although micro array studies on patient and animal tissue provide valuable information, the primary effect of mut...

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Detalhes bibliográficos
Main Authors: van Roon-Mom, Willeke MC, Pepers, Barry A, 't Hoen, Peter AC, Verwijmeren, Carola ACM, den Dunnen, Johan T, Dorsman, Josephine C, van Ommen, GertJan B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588454/
https://ncbi.nlm.nih.gov/pubmed/18844975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-84
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