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A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution

Phosphorylation of the regulatory (R) domain initiates cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel activity. To discover how the function of this domain is determined by its structure, we produced an R domain protein (R8) that spanned residues 708–831 of CFTR. Phosphoryl...

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Bibliografiske detaljer
Main Authors: Ostedgaard, Lynda S., Baldursson, Olafur, Vermeer, Daniel W., Welsh, Michael J., Robertson, Andrew D.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25884/
https://ncbi.nlm.nih.gov/pubmed/10792060
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