A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution

Phosphorylation of the regulatory (R) domain initiates cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel activity. To discover how the function of this domain is determined by its structure, we produced an R domain protein (R8) that spanned residues 708–831 of CFTR. Phosphoryl...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ostedgaard, Lynda S., Baldursson, Olafur, Vermeer, Daniel W., Welsh, Michael J., Robertson, Andrew D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10792060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100588797
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