Effect of mutations in lipooligosaccharide biosynthesis genes on virulence of Haemophilus influenzae type b.

Chemical mutagenesis techniques and genetic transformation methods were used to construct isogenic mutants of Haemophilus influenzae type b (Hib) defective in the ability to synthesize lipooligosaccharide (LOS). A mutant (17B) which expressed a LOS molecule with an altered oligosaccharide was less v...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Cope, L D, Yogev, R, Mertsola, J, Argyle, J C, McCracken, G H, Hansen, E J
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1990
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258818/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1694825/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.7.2343-2351.1990
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