Effect of mutations in lipooligosaccharide biosynthesis genes on virulence of Haemophilus influenzae type b.

Chemical mutagenesis techniques and genetic transformation methods were used to construct isogenic mutants of Haemophilus influenzae type b (Hib) defective in the ability to synthesize lipooligosaccharide (LOS). A mutant (17B) which expressed a LOS molecule with an altered oligosaccharide was less v...

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Bibliographic Details
Main Authors: Cope, L D, Yogev, R, Mertsola, J, Argyle, J C, McCracken, G H, Hansen, E J
Format: Artigo
Language:Inglês
Published: 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC258818/
https://ncbi.nlm.nih.gov/pubmed/1694825
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