Effect of mutations in lipooligosaccharide biosynthesis genes on virulence of Haemophilus influenzae type b.

Chemical mutagenesis techniques and genetic transformation methods were used to construct isogenic mutants of Haemophilus influenzae type b (Hib) defective in the ability to synthesize lipooligosaccharide (LOS). A mutant (17B) which expressed a LOS molecule with an altered oligosaccharide was less v...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Cope, L D, Yogev, R, Mertsola, J, Argyle, J C, McCracken, G H, Hansen, E J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258818/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1694825/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.7.2343-2351.1990
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