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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

HIV-1 entry into CD4(+) cells requires the sequential interactions of the viral envelope glycoproteins with CD4 and a coreceptor such as the chemokine receptors CCR5 and CXCR4. A plausible approach to blocking this process is to use small molecule antagonists of coreceptor function. One such inhibit...

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Publicado en:Proc Natl Acad Sci U S A
Principais autores: Dragic, Tatjana, Trkola, Alexandra, Thompson, Daniah A. D., Cormier, Emmanuel G., Kajumo, Francis A., Maxwell, Elizabeth, Lin, Steven W., Ying, Weiwen, Smith, Steven O., Sakmar, Thomas P., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25881/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10779565/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.090576697
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