A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

HIV-1 entry into CD4(+) cells requires the sequential interactions of the viral envelope glycoproteins with CD4 and a coreceptor such as the chemokine receptors CCR5 and CXCR4. A plausible approach to blocking this process is to use small molecule antagonists of coreceptor function. One such inhibit...

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Main Authors: Dragic, Tatjana, Trkola, Alexandra, Thompson, Daniah A. D., Cormier, Emmanuel G., Kajumo, Francis A., Maxwell, Elizabeth, Lin, Steven W., Ying, Weiwen, Smith, Steven O., Sakmar, Thomas P., Moore, John P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2000
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC25881/
https://ncbi.nlm.nih.gov/pubmed/10779565
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