Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology

Motor learning and neuro-adaptations to drugs of abuse rely upon neuronal signaling in the striatum. Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopamine neurotransmission and behavioral responses to cocaine. Although the role for Cdk5 in neurodegeneration in the cortex and hippocampus and i...

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Detalhes bibliográficos
Main Authors: Meyer, Douglas A., Richer, Edmond, Benkovic, Stanley A., Hayashi, Kanehiro, Kansy, Janice W., Hale, Carly F., Moy, Lily Y., Kim, Yong, O'Callaghan, James P., Tsai, Li-Huei, Greengard, Paul, Nairn, Angus C., Cowan, Christopher W., Miller, Diane B., Antich, Pietro, Bibb, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587606/
https://ncbi.nlm.nih.gov/pubmed/19017804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806078105
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