The role of ventral striatal cAMP signaling in stress-induced behaviors

The cAMP/PKA signaling cascade is a ubiquitous pathway acting downstream of multiple neuromodulators. We found that the phosphorylation of phosphodiesterase-4 (PDE4) by cyclin-dependent protein kinase 5 (Cdk5) facilitates cAMP degradation and homeostasis of cAMP/PKA signaling. In mice, loss of Cdk5...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Plattner, Florian, Hayashi, Kanehiro, Hernandez, Adan, Benavides, David R., Tassin, Tara C., Tan, Chunfeng, Day, Jonathan, Fina, Maggy W., Yuen, Eunice Y., Yan, Zhen, Goldberg, Matthew S., Nairn, Angus C., Greengard, Paul, Nestler, Eric J., Taussig, Ronald, Nishi, Akinori, Houslay, Miles D., Bibb, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519694/
https://ncbi.nlm.nih.gov/pubmed/26192746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4066
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