Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents

We describe herein that a pyrazine derivative, T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide), is protective for a lethal West Nile virus infection in rodents. Oral T-705 at 200 mg/kg administered twice daily beginning 4 hours after subcutaneous (s.c.) viral challenge protected mice and hamsters a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Morrey, John D., Taro, Brandon S., Siddharthan, Venkatraman, Wang, Hong, Smee, Donald F., Christensen, Andrew J., Furuta, Yousuke
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587511/
https://ncbi.nlm.nih.gov/pubmed/18762216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.07.009
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker