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Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents
We describe herein that a pyrazine derivative, T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide), is protective for a lethal West Nile virus infection in rodents. Oral T-705 at 200 mg/kg administered twice daily beginning 4 hours after subcutaneous (s.c.) viral challenge protected mice and hamsters a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587511/ https://ncbi.nlm.nih.gov/pubmed/18762216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.07.009 |
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