Efficacy of Orally Administered T-705 on Lethal Avian Influenza A (H5N1) Virus Infections in Mice

T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) was inhibitory to four strains of avian H5N1 influenza virus in MDCK cells, with the 90% effective concentrations ranging from 1.3 to 7.7 μM, as determined by a virus yield reduction assay. The efficacy was less than that exerted by oseltamivir carbox...

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Main Authors: Sidwell, Robert W., Barnard, Dale L., Day, Craig W., Smee, Donald F., Bailey, Kevin W., Wong, Min-Hui, Morrey, John D., Furuta, Yousuke
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2007
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803113/
https://ncbi.nlm.nih.gov/pubmed/17194832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01051-06
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