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Onconase and Amphinase, the Antitumor Ribonucleases from Rana pipiens Oocytes

Rana pipiens oocytes contain two homologues of pancreatic ribonuclease A that are cytostatic and cytotoxic to human cancer cells. Extensively studied Onconase is in advanced Phase IIIb clinical trials against malignant mesothelioma, while Amphinase is a novel enzyme in pre-clinical development. Onco...

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Bibliographic Details
Main Authors: Ardelt, W., Shogen, K., Darzynkiewicz, Z.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586917/
https://ncbi.nlm.nih.gov/pubmed/18673287
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