Safety, immunogenicity, and efficacy against cholera challenge in humans of a typhoid-cholera hybrid vaccine derived from Salmonella typhi Ty21a.

A live oral vaccine consisting of attenuated Salmonella typhi Ty21a expressing Vibrio cholerae O1 Inaba lipopolysaccharide (LPS) O antigen was constructed and tested in volunteers for safety, immunogenicity, and efficacy. Fourteen adults ingested three doses of 10(10) viable organisms with buffer. O...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Tacket, C O, Forrest, B, Morona, R, Attridge, S R, LaBrooy, J, Tall, B D, Reymann, M, Rowley, D, Levine, M M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1692807/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.6.1620-1627.1990
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