Safety, immunogenicity, and efficacy against cholera challenge in humans of a typhoid-cholera hybrid vaccine derived from Salmonella typhi Ty21a.

A live oral vaccine consisting of attenuated Salmonella typhi Ty21a expressing Vibrio cholerae O1 Inaba lipopolysaccharide (LPS) O antigen was constructed and tested in volunteers for safety, immunogenicity, and efficacy. Fourteen adults ingested three doses of 10(10) viable organisms with buffer. O...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Tacket, C O, Forrest, B, Morona, R, Attridge, S R, LaBrooy, J, Tall, B D, Reymann, M, Rowley, D, Levine, M M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1692807/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.6.1620-1627.1990
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!