Safety, immunogenicity, and efficacy against cholera challenge in humans of a typhoid-cholera hybrid vaccine derived from Salmonella typhi Ty21a.

A live oral vaccine consisting of attenuated Salmonella typhi Ty21a expressing Vibrio cholerae O1 Inaba lipopolysaccharide (LPS) O antigen was constructed and tested in volunteers for safety, immunogenicity, and efficacy. Fourteen adults ingested three doses of 10(10) viable organisms with buffer. O...

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Asıl Yazarlar: Tacket, C O, Forrest, B, Morona, R, Attridge, S R, LaBrooy, J, Tall, B D, Reymann, M, Rowley, D, Levine, M M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1990
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC258689/
https://ncbi.nlm.nih.gov/pubmed/1692807
Etiketler: Etiketle
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