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An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity

The ability to site-specifically methylate DNA in vivo would have wide applicability to the study of basic biomedical problems as well as enable studies on the potential of site-specific DNA methylation as a therapeutic strategy for the treatment of diseases. Natural DNA methyltransferases lack the...

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Hlavní autoři: Meister, Glenna E., Chandrasegaran, Srinivasan, Ostermeier, Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586766/
https://ncbi.nlm.nih.gov/pubmed/18835252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.09.099
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