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AUF1 is upregulated by angiotensin II to destabilize cardiac Kv4.3 channel mRNA
Expression of cardiac myocyte Kv4 channels (Kv4.3 for human, Kv4.2 and Kv4.3 for rodents) is downregulated with hypertrophy in vivo leading to a decrease in the transient outward current (Ito). This effect is recapitulated in vitro with rat neonatal cardiac myocytes treated with angiotensin II (Ang...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586664/ https://ncbi.nlm.nih.gov/pubmed/18789946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2008.08.004 |
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