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Delayed Endosome-dependent CamKII and p38 Kinase Signaling in Cardiomyocytes Destabilizes Kv4.3 mRNA
The Kv4.3 transient outward current (I(to)) channel, which produces early repolarization in human cardiomyocytes, is downregulated with cardiac pathology. This is evident in cultured neonatal rat cardiomyocytes in which Angiotensin II (Ang II) acts via p38 mitogen-activated protein kinase (p38K) to...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3327804/ https://ncbi.nlm.nih.gov/pubmed/22266351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.01.001 |
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