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Bupivacaine Blocks N-Type Inactivating K(v) Channels in the Open State: No Allosteric Effect on Inactivation Kinetics

Local anesthetics bind to ion channels in a state-dependent manner. For noninactivating voltage-gated K channels the binding mainly occurs in the open state, while for voltage-gated inactivating Na channels it is assumed to occur mainly in inactivated states, leading to an allosterically caused incr...

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Main Authors: Nilsson, Johanna, Madeja, Michael, Elinder, Fredrik, Århem, Peter
פורמט: Artigo
שפה:Inglês
יצא לאור: The Biophysical Society 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586568/
https://ncbi.nlm.nih.gov/pubmed/18790854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.130518
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