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Bupivacaine Blocks N-Type Inactivating K(v) Channels in the Open State: No Allosteric Effect on Inactivation Kinetics
Local anesthetics bind to ion channels in a state-dependent manner. For noninactivating voltage-gated K channels the binding mainly occurs in the open state, while for voltage-gated inactivating Na channels it is assumed to occur mainly in inactivated states, leading to an allosterically caused incr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586568/ https://ncbi.nlm.nih.gov/pubmed/18790854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.130518 |
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