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A Tyrosine Substitution in the Cavity Wall of a K Channel Induces an Inverted Inactivation
Ion permeation and gating kinetics of voltage-gated K channels critically depend on the amino-acid composition of the cavity wall. Residue 470 in the Shaker K channel is an isoleucine, making the cavity volume in a closed channel insufficiently large for a hydrated K(+) ion. In the cardiac human eth...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275704/ https://ncbi.nlm.nih.gov/pubmed/18192362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.119842 |
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