Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric-oxide Synthase

Nitric-oxide synthases (NOS) are heme-thiolate enzymes that N-hydroxylate l-arginine (l-Arg) to make NO. NOS contain a unique Trp residue whose side chain stacks with the heme and hydrogen bonds with the heme thiolate. To understand its importance we substituted His for Trp(188) in the inducible NOS...

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Bibliographische Detailangaben
Hauptverfasser: Tejero, Jesús, Biswas, Ashis, Wang, Zhi-Qiang, Page, Richard C., Haque, Mohammad Mahfuzul, Hemann, Craig, Zweier, Jay L., Misra, Saurav, Stuehr, Dennis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586280/
https://ncbi.nlm.nih.gov/pubmed/18815130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806122200
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