Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lung

BACKGROUND: The variable efficacy (0–80%) of Mycobacterium bovis Bacille Calmette Guréin (BCG) vaccine against adult tuberculosis (TB) necessitates development of alternative vaccine candidates. Development of recombinant BCG (rBCG) over-expressing promising immunodominant antigens of M. tuberculosi...

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Main Authors: Jain, Ruchi, Dey, Bappaditya, Dhar, Neeraj, Rao, Vivek, Singh, Ramandeep, Gupta, Umesh D., Katoch, V. M., Ramanathan, V. D., Tyagi, Anil K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586085/
https://ncbi.nlm.nih.gov/pubmed/19052643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003869
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