Enhanced and enduring protection against tuberculosis by recombinant BCG-Ag85C and its association with modulation of cytokine profile in lung.

BACKGROUND: The variable efficacy (0-80%) of Mycobacterium bovis Bacille Calmette Guréin (BCG) vaccine against adult tuberculosis (TB) necessitates development of alternative vaccine candidates. Development of recombinant BCG (rBCG) over-expressing promising immunodominant antigens of M. tuberculosi...

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Main Authors: Ruchi Jain, Bappaditya Dey, Neeraj Dhar, Vivek Rao, Ramandeep Singh, Umesh D Gupta, V M Katoch, V D Ramanathan, Anil K Tyagi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2008-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC2586085?pdf=render
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