Antiproliferative, Low-calcemic, Fluorinated Sulfone Analogs of 1α,25-Dihydroxyvitamin D(3): Chemical Synthesis and Biological Evaluation

Novel fluorinated sulfone analogs of the hormone 1α,25-dihydroxyvitamin D(3) have been designed and synthesized in order to study the biological effects of fluorine incorporation at the terminus of the C,D-ring side chain. Although biologically active 26,27-hexafluorinated 1α,25-dihydroxyvitamin D(3...

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Bibliographic Details
Main Authors: Usera, Aimee R., Dolan, Patrick M., Kensler, Thomas W., Posner, Gary H.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586064/
https://ncbi.nlm.nih.gov/pubmed/17560112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.05.051
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