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Difluoromethyl Analogs of the Natural Hormone 1a,25-Dihydroxyvitamin D(3): Design, Synthesis, and Preliminary Biological Evaluation
Three new vitamin D analogs 3-5 incorporating a –CHF(2) group as an –OH surrogate have been prepared. Two of these new analogs (3 and 5) are strongly antiproliferative toward murine keratinocytes and are approximately 50 times less calciuric in vivo than the natural hormone calcitriol. The transcrip...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2712873/ https://ncbi.nlm.nih.gov/pubmed/17218093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.024 |
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