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Difluoromethyl Analogs of the Natural Hormone 1a,25-Dihydroxyvitamin D(3): Design, Synthesis, and Preliminary Biological Evaluation

Three new vitamin D analogs 3-5 incorporating a –CHF(2) group as an –OH surrogate have been prepared. Two of these new analogs (3 and 5) are strongly antiproliferative toward murine keratinocytes and are approximately 50 times less calciuric in vivo than the natural hormone calcitriol. The transcrip...

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Detalhes bibliográficos
Main Authors: Posner, Gary H., Suh, Byung Chul, Petersen, Kimberly S., Dolan, Patrick, Agoston, Elin S., Kensler, Thomas W., Koh, John T., Peleg, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712873/
https://ncbi.nlm.nih.gov/pubmed/17218093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.024
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