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Novel Alkyl Side Chain Sulfone 1α,25-Dihydroxyvitamin D(3) Analogs: A Comparison of in vitro Antiproliferative Activities and in vivo Calcemic Activities

The replacement of a t-butyl group with a trifluoromethyl group has profound effects on the biological profile of 1α,25-dihydroxyvitamin D(3) sulfone analogs. Investigation of whether the improved biological activities are due to steric and electronic factors of the trifluoromethyl group led to the...

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Autori principali: Usera, Aimee R., Dolan, Patrick, Kensler, Thomas W., Posner, Gary H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713797/
https://ncbi.nlm.nih.gov/pubmed/19577932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.06.033
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