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A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells

A derivative of rhodamine 110 has been designed and assessed as a probe for cytochrome P450 activity. This probe is the first to utilize a “trimethyl lock” that is triggered by cleavage of an ether bond. In vitro, fluorescence was manifested by the CYP1A1 isozyme with k(cat)/K(M) = 8.8 × 10(3) M(−1)...

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Bibliografski detalji
Glavni autori: Yatzeck, Melissa M., Lavis, Luke D., Chao, Tzu-Yuan, Chandran, Sunil S., Raines, Ronald T.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586036/
https://ncbi.nlm.nih.gov/pubmed/18595692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.06.015
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