Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells marked by surface expression of the glycoprotein Tim-3. The frequency of this population was increased in HIV-1–infe...

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Bibliografische gegevens
Hoofdauteurs: Jones, R. Brad, Ndhlovu, Lishomwa C., Barbour, Jason D., Sheth, Prameet M., Jha, Aashish R., Long, Brian R., Wong, Jessica C., Satkunarajah, Malathy, Schweneker, Marc, Chapman, Joan M., Gyenes, Gabor, Vali, Bahareh, Hyrcza, Martin D., Yue, Feng Yun, Kovacs, Colin, Sassi, Aref, Loutfy, Mona, Halpenny, Roberta, Persad, Desmond, Spotts, Gerald, Hecht, Frederick M., Chun, Tae-Wook, McCune, Joseph M., Kaul, Rupert, Rini, James M., Nixon, Douglas F., Ostrowski, Mario A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585847/
https://ncbi.nlm.nih.gov/pubmed/19001139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081398
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