Aberrant B cell receptor signaling from B29 (Igβ, CD79b) gene mutations of chronic lymphocytic leukemia B cells

Chronic lymphocytic leukemia (CLL) B cells characteristically exhibit low or undetectable surface B cell receptor (BCR) and diminished responses to BCR-mediated signaling. These features suggest that CLL cells may have sustained mutations affecting one or more of the BCR proteins required for recept...

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Main Authors: Gordon, Melinda S., Kato, Roberta M., Lansigan, Frederick, Thompson, Alexis A., Wall, Randolph, Rawlings, David J.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25858/
https://ncbi.nlm.nih.gov/pubmed/10792036
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