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Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)

Somatic hypermutation (SHM), coupled to selection by antigen, generates high-affinity antibodies during germinal center (GC) B cell maturation. SHM is known to affect Bcl6, four additional oncogenes in diffuse large B cell lymphoma, and the CD95/Fas gene and is regarded as a major mechanism of B cel...

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Bibliografiset tiedot
Päätekijät: Gordon, Melinda S., Kanegai, Cindy M., Doerr, Jeanette R., Wall, Randolph
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences 2003
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC153059/
https://ncbi.nlm.nih.gov/pubmed/12651942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0735266100
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