Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

To analyze the immunoglobulin repertoire of human IgM+ B cells and the CD5(+) and CD5(-) subsets, individual CD19(+)/ IgM+/CD5(+) or CD5(-) B cells were sorted and non-productive as well as productive VH gene rearrangements were amplified from genomic DNA and sequenced. In both subsets, the VH3 fami...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Brezinschek, H P, Foster, S J, Brezinschek, R I, Dörner, T, Domiati-Saad, R, Lipsky, P E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9153293/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119433
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